NAMPT Proteins, Antibodies, cDNA Clones Research Reagents

NAMPT (Nicotinamide Phosphoribosyltransferase, also known as VF; PBEF; PBEF1; VISFATIN; 1110035O14Rik), located on 7q22.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 55521 Da protein composed of 491 amino acids. This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. Diseases such as Aging and Gestational Diabetes are associated with NAMPT. The related pathways of NAMPT include the Metabolism of water-soluble vitamins and cofactors and NAD metabolism, sirtuins, and aging.

NAMPT Protein (1)

    NAMPT Antibody (1)

      NAMPT cDNA Clone (17)

      NM_005746.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_177928.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NAMPT qPCR Primer (1)

      NAMPT Lysate (1)

        NAMPT 分子背景

        Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin, is an enzyme belonging to the family of glycosyltransferases, to be specific, the pentosyltransferases. This enzyme participates in nicotinate and nicotinamide metabolism. This enzyme catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1- pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. NAMPT is also considered as an essential enzyme mediating granulocyte colony-stimulating factor (G-CSF)-triggered granulopoiesis in healthy individuals and individuals with severe congenital neutropenia. Intracellular NAMPT and NAD+ amounts in myeloid cells, as well as plasma NAMPT and NAD+ levels, were increased by G-CSF treatment of both healthy volunteers and individuals with congenital neutropenia.

        NAMPT 参考文献

        • Skokowa J, et al. (2009) NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD+-sirtuin-1-dependent pathway. Nat Med. 15(2): 151-8.
        • Samal B, et al. (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol. 14 (2): 1431-7.

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