NANS Antibodies, cDNA Clones Research Reagents

NANS (N-Acetylneuraminate Synthase, also known as SAS; SEMDG; SEMDCG; HEL-S-100), located on 9q22.33, is a Protein Coding gene. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. NANS can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant.

NANS Antibody (1)

    NANS cDNA Clone (31)

    NM_018946.3

    克隆载体 cDNA 产品

    NM_053179.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001106655.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NANS qPCR Primer (1)

    NANS 分子背景

    NANS (N-Acetylneuraminate Synthase) is a Protein Coding gene. The NANS gene, located on 9q22.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. Diseases associated with NANS include Spondyloepimetaphyseal Dysplasia, Genevieve Type, and Cleft Palate, Isolated. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins.

    NANS 参考文献

    • van Karnebeek CD, et al. (2016) Nans-mediated synthesis of sialic acid is required for brain and skeletal development. Nat Genet 48 (7): 777-784.
    • Lawrence SM, et al. (2000) Cloning and expression of the human n-acetylneuraminic acid phosphate synthase gene with 2-keto-3-deoxy-d-glycero- d-galacto-nononic acid biosynthetic ability. J Biol Chem 275 (23): 17869-17877.
    • Hamada T, et al. (2006) Solution structure of the antifreeze-like domain of human sialic acid synthase. Protein Sci 15 (5): 1010-1016.

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