NBL1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

NBL1 (NBL1, DAN Family BMP Antagonist, also known as NB; DAN; NO3; DAND1; D1S1733E), located on 1p36.13, is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 19408 Da protein composed of 181 amino acids. This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in some signaling molecules. Diseases such as Neuroblastoma and Ureter, Cancer Of are associated with NBL1. The related pathways of NBL1 include the TGF-beta signaling pathway (KEGG).

NBL1 Protein (3)

    NBL1 Antibody (8)

      NBL1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      NBL1 cDNA Clone (17)

      NM_005380.4

      In expression vector

      In lentiviral vector

      NM_008675.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_031609.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NBL1 Lysate (3)

        NBL1 分子背景

        The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in the vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression, and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante, and PRDC (protein related to DAN and Cerberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in the regulation of the entry of cells into the S phase. Besides, the DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumor suppressor gene for neuroblastoma.

        NBL1 参考文献

        • Ozaki T, et al. (1995) Overexpression of DAN gene product in normal rat fibroblasts causes a retardation of the entry into the S phase. Cancer Res. 55(4): 895-900.
        • Nakamura Y, et al. (1997) A product of DAN, a novel candidate tumour suppressor gene, is secreted into culture medium and suppresses DNA synthesis. Eur J Cancer. 33(12): 1986-90.
        • Ogita J, et al. (2001) Expression of the Dan gene during chicken embryonic development. Mech Dev. 109(2): 363-5.
        • Kim AS, et al. (2003) Expression of the BMP antagonist Dan during murine forebrain development. Brain Res Dev Brain Res. 145(1): 159-62.

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