NEUROD1 Antibodies, cDNA Clones Research Reagents

NEUROD1 (Neuronal Differentiation 1, also known as T2D; BETA2; BHF-1; MODY6; NEUROD; bHLHa3), located on 2q31.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 39920 Da protein composed of 356 amino acids. This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. Diseases such as Maturity-Onset Diabetes Of The Young, Type 6, and Diabetes Mellitus, Noninsulin-Dependent are associated with NEUROD1. The related pathways of NEUROD1 include Neuroscience and Regulation of beta-cell development.

NEUROD1 Antibody (1)

    NEUROD1 cDNA Clone (17)

    NM_002500.4

    In expression vector

    NM_010894.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NEUROD1 qPCR Primer (1)

    NEUROD1 分子背景

    NEUROD1 (Neuronal Differentiation 1, also known as BETA2) is a Protein Coding gene. NEUROD1 encodes a transcription factor expressed in the endocrine pancreas and involved in beta-cell development, function, and mechanisms of apoptosis. The protein is a tissue-specific basic helix loop helix (bHLH) protein involved in the development and maintenance of the endocrine pancreas and neuronal elements. It forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. NEUROD1 is expressed in both developing and mature beta-cells. Loss of NEUROD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. Diseases associated with NEUROD1 include Maturity-Onset Diabetes Of The Young, Type 6 and Diabetes Mellitus, Noninsulin-Dependent.

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