Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
1. Wang, X. et al., 2006, Ann Neurol. 60(5): 540-549.
2. Wang, Y.Z. et al., 2006, Neuroreport.17(6):605-609.
3. Zhu, H.Y. et al., 2007, Hum Pathol. 38(3): 426-434.
4. David, S. et al., 2008, Trends Neurosci. 31(5): 221-226.
5. Jiang, W. et al., 2009, Transl Res. 154(1): 40-48.
6. Zhang, L. et al., 2009, J Neurosci, 9(19): 6348-6352.