Nogo Receptor/RTN4R Proteins, Antibodies, cDNA Clones Research Reagents

RTN4R (Reticulon 4 Receptor) is a protein coding gene located on human chromosome 22q11.21. RTN4R is also known as NGR and NOGOR. The human RTN4R gene encodes a 50708 Da protein containing 473 amino acids. Biased expression in brain (RPKM 7.7), spleen (RPKM 2.5) and 10 other tissues Among its related pathways are Guidance Cues and Growth Cone Motility and p75(NTR)-mediated signaling. RTN4RL2 is an important paralog of RTN4R gene. RTN4R is associated with some diseases, including Schizophrenia and Leukemia, Acute Lymphoblastic.

Nogo Receptor/RTN4R Protein (4)

    Nogo Receptor/RTN4R Antibody (3)

      Nogo Receptor/RTN4R cDNA Clone (26)

      NM_023004.5

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_022982.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Nogo Receptor/RTN4R Lysate (4)

        Nogo Receptor/RTN4R 分子背景

        Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

        Nogo Receptor/RTN4R 参考文献

          1. Wang, X. et al., 2006, Ann Neurol. 60(5): 540-549.      

          2. Wang, Y.Z. et al., 2006, Neuroreport.17(6):605-609.       

          3. Zhu, H.Y. et al., 2007, Hum Pathol. 38(3): 426-434.           

          4. David, S. et al., 2008, Trends Neurosci. 31(5): 221-226.       

          5. Jiang, W. et al., 2009, Transl Res. 154(1): 40-48.      

          6. Zhang, L. et al., 2009, J Neurosci, 9(19): 6348-6352.

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