NOTCH1 Proteins, Antibodies Research Reagents

NOTCH1 (Notch Receptor 1, also known as hN1; AOS5; TAN1; AOVD1), located on 9q34.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces a 272505 Da protein composed of 2555 amino acids. This gene encodes a member of the NOTCH family of proteins. NOTCH1 is ubiquitously expressed in fat, spleen, and other tissues. Diseases such as Aortic Valve Disease 1 and Adams-Oliver Syndrome 5 are associated with NOTCH1. The related pathways of NOTCH1 include Neuroscience and Gene regulatory network modeling somitogenesis.

NOTCH1 Protein (3)

    NOTCH1 Antibody (4)

      NOTCH1 Lysate (3)

        NOTCH1 分子背景

        NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair the regeneration of skeletal muscles.NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL). The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems. The proto-oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). NOTCH1 mutations in oral squamous cell carcinoma (OSCC) frequently occur near the ligand-binding region. These mutations change the domain structure of this protein and affect the ligand-binding activity. When NOTCH1 is activated by ligand binding, the NOTCH1 intracellular domain (NICD) is cleaved from the cell membrane.

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