NOV/CCN3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

CCN3 (Cellular Communication Network Factor 3, also known as NOV; NOVh; IBP-9; IGFBP9; IGFBP-9), located on 8q24.12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 39162 Da protein composed of 357 amino acids. The encoded protein is a small secreted cysteine-rich protein. It belongs to the CCN family of regulatory proteins. Diseases such as Wilms Tumor 5 and Rhabdomyosarcoma are associate with CCN3. The related pathways of CCN3 include Notch Signaling Pathway (WikiPathways) and Adhesion.

NOV/CCN3 Protein (3)

    NOV/CCN3 Antibody (7)

      NOV/CCN3 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      NOV/CCN3 cDNA Clone (52)

      NM_002514.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010930.4

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_532317.3

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001097136.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NOV/CCN3 Lysate (3)

        NOV/CCN3 分子背景

        Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix, and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development, and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signaling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of some cell lineages including hematopoietic, osteogenic, and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis, and a crucial component within the bone marrow microenvironment.

        NOV/CCN3 参考文献

        • Manara MC, et al. (2002) The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol. 160(3): 849-59.
        • Lin CG, et al. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 278(26): 24200-8.
        • Vallacchi V, et al. (2009) CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma. Cancer Res. 68(3): 715-23.
        • Sin WC, et al. (2009) Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization. J Biol Chem. 284(43): 29935-44.
        • McCallum L, et al. (2009) CCN3--a key regulator of the hematopoietic compartment. Blood Rev. 23(2): 79-85.

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