Nrf2/NFE2L2 Antibodies, cDNA Clones Research Reagents

NFE2L2 (Nuclear Factor, Erythroid 2 Like 2, also known as NRF2; HEBP1; IMDDHH), located on 2q31.2, is a Protein Coding gene. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The gene produces a 67827 Da protein composed of 605 amino acids. NFE2L2 is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), are critical in the maintenance of redox, metabolic and protein homeostasis, as well as the regulation of inflammation.

Nrf2/NFE2L2 Antibody (2)

    Nrf2/NFE2L2 cDNA Clone (22)

    NM_006164.4

    克隆载体 cDNA 产品

    In lentiviral vector

    In expression vector

    NM_010902.3

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_006234396.2

    克隆载体 cDNA 产品

    In expression vector

    In lentiviral vector

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    Nrf2/NFE2L2 分子背景

    The nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in the placentas is associated with pregnancy complications. Phosphorylation of the transcription factor NFE2L2 controls mRNA abundance of genes encoding antioxidant proteins and enzymes. NFE2L2 pathway contributes to the environmental resistance of cancers by enhancing the antioxidant capacity. Nrf2 (encoded in humans by the NFE2L2 gene) is the master regulator of antioxidant defenses, a transcription factor that regulates the expression of more than 200 cytoprotective genes. Increasing evidence indicates that Nrf2 signaling plays a key role in how oxidative stress mediates the beneficial effects of exercise. NRF2 and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), are critical in the maintenance of redox, metabolic and protein homeostasis, as well as the regulation of inflammation.

    Nrf2/NFE2L2 参考文献

    • Wu J, et al. (2017) Placental nfe2l2 is discordantly activated in monochorionic twins with selective intrauterine growth restriction and possibly regulated by hypoxia. Free Radic Res 51 (4): 351-359.
    • Jung KA, et al. (2017) Nfe2l2/nrf2 activity is linked to mitochondria and amp-activated protein kinase signaling in cancers through mir-181c/mitochondria-encoded cytochrome c oxidase regulation. Antioxid Redox Signal 27 (13): 945-961.
    • Han LQ, et al. (2018) Phosphorylation of nuclear factor erythroid 2-like 2 (nfe2l2) in mammary tissue of holstein cows during the periparturient period is associated with mrna abundance of antioxidant gene networks. J Dairy Sci 101 (7): 6511-6522.
    • Done AJ, et al. (2016) Nrf2 mediates redox adaptations to exercise. Redox Biol 10 191-199.

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