NRG2 Proteins, cDNA Clones Research Reagents

NRG2 (Neuregulin 2) is a protein coding gene located on human chromosome 5q31.2. NRG2 is also known as DON1, HRG2 and NTAK. The human NRG2 gene encodes a 91679 Da protein containing 850 amino acids. The NRG2 protein is broadly expressed in ovary, fat and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. NRG2 is related to signaling receptor binding and growth factor activity. NRG1 is an important paralog of NRG2 gene. NRG2 is associated with some diseases, including Dysbaric Osteonecrosis and Charcot-Marie-Tooth Disease.

NRG2 Protein (1)

    NRG2 cDNA Clone (1)

    NM_004883.2

    克隆载体 cDNA 产品

    NRG2 Lysate (1)

      NRG2 分子背景

      Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction.

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