Nonstructural protein 2/NS2 Proteins Research Reagents

Non-structural protein 2 (NS2, also known as NEP) is encoded by the spliced mRNA generated from segment 8, and its primordial role is to drive the export of progeny RNPs from the nucleus by interaction with M1 protein and the CRM1-dependent export system. NS2 of influenza A virus contains a leucine-rich nuclear export signal that could guide viral ribonucleoproteins to cross the nuclear pore complex (NPC) and complete directional nucleocytoplasmic trafficking. NS2 plays a critical role in the nuclear exit of viral RNP into the cytoplasm and eventual transport to the budding site.

Nonstructural protein 2/NS2 Protein (1)

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    Nonstructural protein 2/NS2 分子背景

    Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and antiviral effects of the aptamers were examined. The non-structural protein NS2, also called nuclear export protein, of influenza A virus contains a leucine-rich nuclear export signal that could guide viral ribonucleoproteins to cross the nuclear pore complex (NPC) and complete directional nucleocytoplasmic trafficking.

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