OMGP Proteins, Antibodies, cDNA Clones Research Reagents

All OMGP reagents are produced in house and quality controlled, including 3 OMGP Antibody, 39 OMGP Gene, 3 OMGP Lysate, 3 OMGP Protein, 2 OMGP qPCR. All OMGP reagents are ready to use.

OMGP Protein (3)

    OMGP Antibody (3)

      OMGP cDNA Clone (39)

      NM_002544.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001260823.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_002718940.1

      克隆载体 cDNA 产品

      In lentiviral vector

      OMGP Lysate (3)

        OMGP 分子背景

        Oligodendrocyte-myelin glycoprotein, also known as OMG and OMGP, is a cell membrane protein which contains eightLRR (leucine-rich) repeats. OMG / OMGP is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS). OMG / OMGP is a cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system. OMG / OMGP play roles in both the developing and adult central nervous system. OMG / OMGP participats in growth cone collapse and inhibition of neurite outgrowth through its interaction with NgR, the receptor for Nogo. This function requires its leucine-rich repeat domain, a highly conserved region in OMgp during mammal evolution. OMG / OMGP leucine-rich repeat domain is also implicated in the inhibition of cell proliferation. OMG / OMGP may also be involved in the formation and maintenance of myelin sheaths. Cell proliferation, neuronal sprouting and myelination are crucial processes involved in brain development and regeneration after injury.

        OMGP 参考文献

        • Viskochil D., et al.,(1991), The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Mol. Cell. Biol. 11:906-912.
        • Mikol D.D., et al., (1990), The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate.J. Cell Biol. 110:471-479.
        • Mikol D.D., et al.,(1990), Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein.J. Cell Biol. 111:2673-2679.

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