OTX2 Antibodies, cDNA Clones Research Reagents

OTX2 (Orthodenticle Homeobox 2) is a protein coding gene located on human chromosome 14q22.3. OTX2 is also known as CPHD6 and MCOPS5. The human OTX2 gene encodes a 31636 Da protein containing 289 amino acids. Among its related pathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Mesodermal Commitment Pathway. OTX2 is related to DNA-binding transcription factor activity and protein heterodimerization activity. OTX1 is an important paralog of OTX2 gene. OTX2 is associated with some diseases, including Microphthalmia, Syndromic 5 and Pituitary Hormone Deficiency, Combined, 6.

OTX2 Antibody (1)

    OTX2 cDNA Clone (1)


    In expression vector

    OTX2 分子背景

    OTX2 is a member of a highly conserved family of bicoid-like homeodomain transcription factors responsible for the regulation of cerebellar development. Orthodenticle homeobox 2 (OTX2) controls essential, homeostatic retinal pigment epithelial (RPE) genes in the adult. Mutations in OTX2 are mostly identified in patients with anophthalmia/microphthalmia with variable severity. The OTX2 homeobox gene plays a crucial role in craniofacial morphogenesis during early embryo development. Otx2 knockout embryos fail to form a head. The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development.

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