P-Selectin Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SELP (Selectin P) is a protein coding gene located on human chromosome 1q24.2. SELP is also known as CD62, GRMP, PSEL, CD62P, GMP140, LECAM3 and PADGEM. The human SELP gene encodes a 90834 Da protein containing 830 amino acids. The SELP protein is broadly expressed in urinary bladder, appendix and other tissues. Among its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. SELP is related to carbohydrate binding and calcium-dependent protein binding. SELE is an important paralog of SELP gene. SELP is associated with some diseases, including Intermittent Claudication and Arteriosclerosis Obliterans.

P-Selectin Protein (8)

    P-Selectin Antibody (13)

      P-Selectin ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      P-Selectin cDNA Clone (52)

      NM_003005.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011347.2

      克隆载体 cDNA 产品

      In lentiviral vector

      BC101919.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001094728.2

      克隆载体 cDNA 产品

      In lentiviral vector

      P-Selectin Lysate (8)

        P-Selectin 分子背景

        P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes.

        P-Selectin 参考文献

        • Johnson-Tidey RR, et al. (1994) Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. Am J Pathol. 144(5):952-61.
        • Walcheck B, et al. (1996) Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest. 98(5):1081-7.
        • Foreman KE, et al. (1994) C5a-induced expression of P-selectin in endothelial cells. J Clin Invest. 94(3):1147-55.

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