p100/p52 Antibodies, cDNA Clones Research Reagents

NFKB2 (Nuclear Factor Kappa B Subunit 2) is a protein coding gene located on human chromosome 10q24.32. NFKB2 is also known as p52, p100, H2TF1, LYT10, CVID10, LYT-10, NF-kB2 and p49/p100. The human NFKB2 gene encodes a 96749 Da protein containing 900 amino acids. The NFKB2 protein is ubiquitously expressed in appendix, bone marrow and other tissues. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Folate Metabolism. NFKB2 is related to DNA-binding transcription factor activity and transcription coactivator activity. NFKB1 is an important paralog of NFKB2 gene. NFKB2 is associated with some diseases, including Immunodeficiency, Common Variable, 10 and Immunodeficiency, Common Variable, 1.

p100/p52 Antibody (1)

    p100/p52 cDNA Clone (1)

    NM_001077494.3

    In expression vector

    p100/p52 分子背景

    NFKB2 encodes the p100/p52 protein, a critical mediator of the canonical and noncanonical NFkB signaling pathways. NFKB2 is a member of the NFKB/Rel gene family, which is known to be a pivotal regulator of the acute phase and immune responses. NF-kappaB2 is initially synthesized as a approximately 100 000 Mr protein which needs to be processed in order to bind DNA, either as homodimer or as heterodimer with other members of the NF-kappaB/Rel family. NFKB2 is ubiquitously expressed, highest in lymph nodes and thymus, underlining its role in the immune function.

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