Parathyroid Hormone/PTH Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PTH (Parathyroid Hormone) is a protein coding gene located on human chromosome 11p15.3. PTH is also known as FIH1 and PTH1. The human PTH gene encodes a 12861 Da protein containing 115 amino acids. Among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Signaling by GPCR. PTH is related to hormone activity and peptide hormone receptor binding. PTH is associated with some diseases, including Hypoparathyroidism, Familial Isolated, 1 and Familial Isolated Hypoparathyroidism.

Parathyroid Hormone/PTH Protein (2)

    Parathyroid Hormone/PTH Antibody (3)

      Parathyroid Hormone/PTH ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      Parathyroid Hormone/PTH cDNA Clone (13)

      NM_000315.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Parathyroid Hormone/PTH Lysate (1)

        Parathyroid Hormone/PTH 分子背景

        Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone (PTH) has been proved to play a pivotal role in maintaining myocardial contractility as well as effective natriuresis, and possible pathogenic mechanisms contributing to heart failure secondary to hypocalcemia and hypoparathyroidism. With the increased population of preosteoblastic lineages and the osteoblastic activation, Parathyroid hormone (PTH) drives anabolism in bone. Experiments have recently reported that PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps.

        Parathyroid Hormone/PTH 参考文献

        • Bedi B, et al. (2012) Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A. 109(12): 725-33.
        • Hasegawa T, et al. (2012) Parathyroid hormone as a Bone anabolic agent. Biological function of bone cells on the PTH-driven anabolic effect. Clin Calcium. 22(3): 373-9.
        • Ito M. Parathyroid hormone as a Bone anabolic agent. Effect of PTH on bone structural properties. Clin Calcium. 22(3): 335-41.

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