PC4/SUB1 Proteins, Antibodies, cDNA Clones Research Reagents

SUB1 (SUB1 Regulator Of Transcription) is a protein coding gene located on human chromosome 5p13.3. SUB1 is also known as P15, PC4 and p14. The human SUB1 gene encodes a 14395 Da protein containing 127 amino acids. The SUB1 protein is ubiquitously expressed in brain, fat and other tissues. SUB1 is related to single-stranded DNA binding. SUB1 is associated with some diseases, including Atrial Septal Defect 4 and Indolent Systemic Mastocytosis.

PC4/SUB1 Protein (1)

    PC4/SUB1 Antibody (3)

      PC4/SUB1 cDNA Clone (30)


      克隆载体 cDNA 产品

      In lentiviral vector


      克隆载体 cDNA 产品

      In lentiviral vector

      PC4/SUB1 qPCR Primer (1)

      PC4/SUB1 分子背景

      SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 binds single-stranded DNA. Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their importance during transcription remains unclear. SUB1 exhibits strong genetic interactions with factors necessary for promoter melting. It localizes near the transcription bubble in vitro and binds to promoters in vivo dependent upon preinitiation complexes assembly. SUB1 interacts with the nontemplate strand of RNApII complexes during initiation. It may also be involved in stabilizing the multiprotein transcription complex.

      PC4/SUB1 参考文献

      • Knaus R, et al. (1996) Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4. EMBO J. 15(8):1933-40.
      • Ge H, et al. (1994) Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell. 78(3):513-23.
      • Kaiser K, et al. (1994) A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell. 78(3):525-34.

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