PDGF-B Proteins, Antibodies, cDNA Clones Research Reagents

PDGFB (Platelet Derived Growth Factor Subunit B) is a protein coding gene located on human chromosome 22q13.1. PDGFB is also known as SIS, SSV, IBGC5, PDGF2, c-sis and PDGF-2. The human PDGFB gene encodes a 27283 Da protein containing 241 amino acids. The PDGFB protein is broadly expressed in placenta, fat and other tissues. Among its related pathways are RET signaling and Phospholipase D signaling pathway. PDGFB is related to protein homodimerization activity and protein heterodimerization activity. PDGFA is an important paralog of PDGFB gene. PDGFB is associated with some diseases, including Dermatofibrosarcoma Protuberans and Basal Ganglia Calcification, Idiopathic, 5.

PDGF-B Protein (5)

PDGF-B Antibody (1)

    PDGF-B cDNA Clone (65)

    NM_002608.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_011057.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_031524.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_001097395.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001003383.1

    克隆载体 cDNA 产品

    In lentiviral vector

    PDGF-B Lysate (1)

      PDGF-B 分子背景

      Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor.

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