PDLIM1 Antibodies, cDNA Clones Research Reagents

PDLIM1 (PDZ And LIM Domain 1, also known as CLIM1; CLP36; CLP-36; hCLIM1; HEL-S-112), located on 10q23.33, is a Protein Coding gene. This gene encodes a member of the enigma protein family. The gene produces a 36072 Da protein composed of 329 amino acids. Sequence analysis predicted that the 329-amino acid PDLIM1 protein, which is 88% homologous to the rat protein, shares 51 to 61% identity with the PDZ domains of ENIGMA, ALP, ENH, and RIL. Diseases such as Supravalvular Aortic Stenosis and Donohue Syndrome are associated with PDLIM1.

PDLIM1 Antibody (1)

    PDLIM1 cDNA Clone (60)

    NM_020992.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_016861.4

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_017365.2

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_004749628.1

    克隆载体 cDNA 产品

    In lentiviral vector

    PDLIM1 qPCR Primer (1)

    PDLIM1 分子背景

    PDLIM1 (PDZ And LIM Domain 1) is a Protein Coding gene. The PDLIM1 gene, located on 10q23.33, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene encodes a member of the enigma protein family. The protein contains two protein-interacting domains, a PDZ domain at the amino-terminal end and one to three LIM domains at the carboxyl-terminal. PDLIM1 is widely expressed in the small intestine, colon, and other tissues, and the protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14, and 17. Diseases associated with PDLIM1 include Supravalvular Aortic Stenosis and Donohue Syndrome.

    PDLIM1 参考文献

    • Miehe U, et al. (2006) Expression of the actin stress fiber-associated protein clp36 in the human placenta. Histochem Cell Biol 126 (4): 465-471.
    • Liu Z, et al. (2015) Pdz and lim domain protein 1(pdlim1)/clp36 promotes breast cancer cell migration, invasion and metastasis through interaction with α-actinin. Oncogene 34 (10): 1300-1311.
    • Kotaka M, et al. (1999) Characterization of the human 36-kda carboxyl terminal lim domain protein (hclim1). J Cell Biochem 72 (2): 279-285.

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