Pepsinogen C/PGC Proteins, Antibodies, cDNA Clones Research Reagents

PGC (Progastricsin) is a protein coding gene located on human chromosome 6p21.1. PGC is also known as PEPC and PGII. The human PGC gene encodes a 42426 Da protein containing 388 amino acids. The PGC protein is restrictedly expressed toward stomach. PGC is related to aspartic-type endopeptidase activity. PGA5 is an important paralog of PGC gene. PGC is associated with some diseases, including Gastritis and Atrophic Gastritis.

Pepsinogen C/PGC Protein (3)

    Pepsinogen C/PGC Antibody (8)

      Pepsinogen C/PGC cDNA Clone (26)

      NM_002630.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_133284.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Pepsinogen C/PGC Lysate (2)

        Pepsinogen C/PGC 分子背景

        Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

        Pepsinogen C/PGC 参考文献

        • Richter C, et al. (1998) Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. Biochem J. 1 (335): 481-90.
        • Westerveld BD, et al. (1987) Gastric proteases in Barrett's esophagus. Gastroenterology. 93 (4): 774-8.
        • Ichinose M, et al. (1991) Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer. Jpn J Cancer Res. 82 (6): 686-92.

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