PIG3 Proteins, Antibodies, cDNA Clones Research Reagents

TP53I3 (Tumor Protein P53 Inducible Protein 3) is a protein coding gene located on human chromosome 2p23.3. TP53I3 is also known as PIG3. The human TP53I3 gene encodes a 35536 Da protein containing 332 amino acids. The TP53I3 protein is broadly expressed in esophagus, small intestine and other tissues. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene Expression. TP53I3 is related to protein homodimerization activity and transferase activity, transferring acyl groups other than amino-acyl groups. VAT1 is an important paralog of TP53I3 gene. TP53I3 is associated with some diseases, such as Lung Adenoma.

PIG3 Protein (1)

    PIG3 Antibody (4)

      PIG3 cDNA Clone (16)

      BC000474

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001113775.1

      克隆载体 cDNA 产品

      PIG3 qPCR Primer (1)

      PIG3 分子背景

      Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3.

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