PIK3CA Antibodies, cDNA Clones Research Reagents

PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha) is a protein coding gene located on human chromosome 3q26.32. PIK3CA is also known as MCM, CWS5, MCAP, PI3K, CLAPO, CLOVE, MCMTC, PI3K-alpha and p110-alpha. The human PIK3CA gene encodes a 124284 Da protein containing 1068 amino acids. The PIK3CA protein is ubiquitously expressed in fat, gall bladder and other tissues. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and RET signaling. PIK3CA is related to transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. PIK3CB is an important paralog of PIK3CA gene. PIK3CA is associated with some diseases, including Hepatocellular Carcinoma and Megalencephaly-Capillary Malformation-Polymicrogyria Syndrome.

PIK3CA Antibody (1)

    PIK3CA cDNA Clone (3)

    NM_006218.3

    In expression vector

    NM_008839.2

    In expression vector

    PIK3CA 分子背景

    Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 11 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22.

    PIK3CA 参考文献

    • Limaye N, Kangas J, Mendola A, et al. Somatic Activating PIK3CA Mutations Cause Venous Malformation. American Journal of Human Genetics. 2015;97(6):914-921.

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