PLA2G1B Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

PLA2G1B (Phospholipase A2 Group IB) is a protein coding gene located on human chromosome 12q24.31. PLA2G1B is also known as PLA2, PLA2A and PPLA2. The human PLA2G1B gene encodes a 16360 Da protein containing 148 amino acids. The PLA2G1B protein is restrictedly expressed toward pancreas. Among its related pathways are Sweet Taste Signaling and Acyl chain remodelling of PE. PLA2G1B is related to calcium ion binding and phospholipase A2 activity. PLA2G2A is an important paralog of PLA2G1B gene. PLA2G1B is associated with some diseases, including Blepharitis and Membranous Nephropathy.

PLA2G1B Protein (2)

    PLA2G1B Antibody (8)

      PLA2G1B ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      PLA2G1B cDNA Clone (26)

      NM_000928.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011107.1

      克隆载体 cDNA 产品

      In lentiviral vector

      PLA2G1B Lysate (2)

        PLA2G1B 分子背景

        phospholipase A2, also known as Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2, PLA2 and PLA2G1B, is a secreted protein that belongs to the phospholipase A2 family. Phospholipase A2 / PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic Phospholipase A2 / PLA2G1B enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of Phospholipase A2 / PLA2G1B have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets. Mice lacking in Phospholipase A2 / PLA2G1B are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. Oral supplementation of a diabetogenic diet with the PLA2G1B inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes. PLA2G1B inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes.

        PLA2G1B 参考文献

        • Labonté,E.D. et al., 2006, Diabetes. 55 (4) :935-41.
        • Mounier,C.M. et al.,2008, Br J Cancer. 98 (3):587-95.
        • Hui,D.Y. et al., 2009, Br J Pharmacol. 157 (7):1263-9.
        • Labonté,E.D. et al., 2010, FASEB J. 24 (7):2516-24.

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