PR-Set7 Proteins, Antibodies, cDNA Clones Research Reagents

KMT5A (Lysine Methyltransferase 5A) is a protein coding gene located on human chromosome 12q24.31. KMT5A is also known as SET8, SET07, SETD8, PR-Set7, and PR/SET07. The human KMT5A gene encodes a 42890 Da protein containing 393 amino acids. The KMT5A protein is ubiquitously expressed in prostate, esophagus and other tissues. Among its related pathways are Mitotic Prophase and Lysine degradation. KMT5A is associated with some diseases, such as Meier-Gorlin Syndrome 1.

PR-Set7 Protein (1)

    PR-Set7 Antibody (4)

      PR-Set7 cDNA Clone (2)

      NM_020382.3

      In expression vector

      In lentiviral vector

      PR-Set7 qPCR Primer (1)

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      PR-Set7 分子背景

      KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a regulator for lipid metabolism in papillary thyroid carcinoma.

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