PRKCB Antibodies, cDNA Clones Research Reagents

PRKCB (Protein Kinase C Beta, also known as PKCB; PRKCB1; PRKCB2; PKCI(2); PKCbeta; PKC-beta), located on 16p12.2-p12.1, is a Protein Coding gene. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. The PRKCB1 gene consists of 18 exons spanning 375 kb, with a particularly large intron of over 150 kb between exons 2 and 3. Exons range from 32 to 174 bp in length. The gene produces a 76869 Da protein composed of 671 amino acids.

PRKCB Antibody (1)

    PRKCB cDNA Clone (30)

    NM_002738.6

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_008855.2

    克隆载体 cDNA 产品

    In lentiviral vector

    PRKCB 分子背景

    PRKCB (Protein Kinase C Beta) is a Protein Coding gene. The PRKCB gene, located on 16p12.2-p12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.pombe, and frog. PRKCB was determined to consist of 18 exons covering approximately 375 kb, with a particularly large intron of over 150 kb between exons 2 and 3. PRKCB is nearly 19 times larger than the highly homologous Drosophila melanogaster protein kinase C gene (dPKC), which has a similar-sized open reading frame but only 13 exons. This increase in size has occurred mostly as a result of the expansion of introns, with intron size in the human gene averaging 22 kb compared with 1.5 kb in dPKC. Diseases associated with PRKCB include Diabetic Macular Edema and Microvascular Complications Of Diabetes 5.

    PRKCB 参考文献

    • Zhu Z, et al. (2018) Increased expression of prkcb mrna in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Ann Hum Genet 82 (4): 200-205.
    • Kawashima M, et al. (2017) Genome-wide association studies identify prkcb as a novel genetic susceptibility locus for primary biliary cholangitis in the japanese population. Hum Mol Genet 26 (3): 650-659.
    • Greenham J, et al. (1998) Elucidation of the exon-intron structure and size of the human protein kinase c beta gene (prkcb). Hum Genet 103 (4): 483-487.

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