PRKCB (Protein Kinase C Beta) is a Protein Coding gene. The PRKCB gene, located on 16p12.2-p12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.pombe, and frog. PRKCB was determined to consist of 18 exons covering approximately 375 kb, with a particularly large intron of over 150 kb between exons 2 and 3. PRKCB is nearly 19 times larger than the highly homologous Drosophila melanogaster protein kinase C gene (dPKC), which has a similar-sized open reading frame but only 13 exons. This increase in size has occurred mostly as a result of the expansion of introns, with intron size in the human gene averaging 22 kb compared with 1.5 kb in dPKC. Diseases associated with PRKCB include Diabetic Macular Edema and Microvascular Complications Of Diabetes 5.