Prokineticin 1/EG-VEGF Proteins, cDNA Clones Research Reagents

PROK1 (Prokineticin 1) is a protein coding gene located on human chromosome 1p13.3. PROK1 is also known as PK1, PRK1 and EGVEGF. The human PROK1 gene encodes a 11715 Da protein containing 105 amino acids. The PROK1 protein is biasedly expressed in ovary, testis and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. PROK1 is related to growth factor activity. PROK2 is an important paralog of PROK1 gene. PROK1 is associated with some diseases, including Ectopic Pregnancy and Pancreatic Adenocarcinoma.

Prokineticin 1/EG-VEGF Protein (1)

    Prokineticin 1/EG-VEGF cDNA Clone (28)

    NM_032414.2

    克隆载体 cDNA 产品

    In lentiviral vector

    BC042707.1

    克隆载体 cDNA 产品

    In lentiviral vector

    Prokineticin 1/EG-VEGF qPCR Primer (1)

    Prokineticin 1/EG-VEGF Lysate (1)

      Prokineticin 1/EG-VEGF 分子背景

      EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEGF can be detected in the steroidogenic glands, ovary, testis, adrenal and placenta. EG-VEGF has little or no effect on a variety of other endothelial and non-endothelial cell types. It induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. EG-VEGF may play a role in placentation. It may also function in normal and pathological testis angiogenesis. It positively regulates PTGS2 expression and prostaglandin synthesis.

      Prokineticin 1/EG-VEGF 参考文献

      • Masuda Y, et al. (2002) Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Biochem. Biophys. Res. Commun. 293 (1): 396-402.
      • Pasquali D. et al. (2006) The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy. Endocrinology. 147 (9): 4245-51.
      • Ngan ES, et al. (2008) Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells. Biochim Biophys Acta. 1783 (3): 467-78.
      • Ngan ES, et al. (2007) Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells. Biochim Biophys Acta. 1773 (4): 536-45.

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