PSCA Antibodies, cDNA Clones Research Reagents

PSCA (Prostate Stem Cell Antigen) is a protein coding gene located on human chromosome 8q24.3. PSCA is also known as PRO232. The human PSCA gene encodes a 11959 Da protein containing 114 amino acids. The PSCA protein is biasedly expressed in stomach, urinary bladder and other tissue. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. LY6E is an important paralog of PSCA gene. PSCA is associated with some diseases, including Gallbladder Adenocarcinoma and Transitional Cell Carcinoma.

PSCA Antibody (2)

    PSCA cDNA Clone (3)


    In expression vector


    In expression vector


    In expression vector


    PSCA 分子背景

    Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Knockdown of PSCA induced EMT and reduced metastatic potentials of the DU145 cells, suggesting that PSCA played an important role in prostatic carcinogenesis and progression. PSCA gene plays an important role in cell adhesion, proliferation and survival. Increasing studies have focused on the association of PSCA gene rs2294008 C>T and rs2976392 G>A with cancer risk.PSCA expression is detected in over 80% of patients with local disease, and elevated levels of PSCA are correlated with increased tumor stage, grade, and androgen independence, including high expression in bone metastases.

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