PTH1R Proteins, Antibodies, cDNA Clones Research Reagents

PTH1R (Parathyroid Hormone 1 Receptor) is a protein coding gene located on human chromosome 3p21.31. PTH1R is also known as PFE, EKNS, PTHR and PTHR1. The human PTH1R gene encodes a 66361 Da protein containing 593 amino acids. The PTH1R protein is biasedly expressed in kidney, adrenal and other tissues. Among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Signaling by GPCR. PTH1R is related to G protein-coupled receptor activity and protein self-association. PTH2R is an important paralog of PTH1R gene. PTH1R is associated with some diseases, including Chondrodysplasia, Blomstrand Type and Metaphyseal Chondrodysplasia, Jansen Type.

PTH1R Protein (1)

    PTH1R Antibody (3)

      PTH1R cDNA Clone (15)

      BC031578

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_000316.2

      In expression vector

      NM_011199.2

      In expression vector

      PTH1R qPCR Primer (1)

      PTH1R Lysate (1)

        PTH1R 分子背景

        Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C. In bone, PTH1R is expressed on the surface of osteoblasts. When the receptor is activated, these cells in turn stimulate osteoclasts to ultimately increase the resorption rate. PTH1R is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of PTH1R is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in PTH1R are the cause of Jansen metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), enchondromatosis multiple (ENCHOM), Eiken skeletal dysplasia (EISD) and primary failure of tooth eruption (PFE).

        PTH1R 参考文献

        • Schipani E., et al., 1993, Endocrinology 132:2157-2165.
        • Hopyan S., et al., 2002, Nat. Genet. 30:306-310.
        • Bastepe M., et al., 2004, J. Clin. Endocrinol. Metab. 89:3595-3600.
        • Duchatelet S., et al., 2005, Hum. Mol. Genet. 14:1-5.
        • Decker E., et al., 2008, Am. J. Hum. Genet. 83:781-786.

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