RbAp48 Proteins, Antibodies, cDNA Clones Research Reagents

RBBP4 (RB Binding Protein 4, Chromatin Remodeling Factor) is a protein coding gene located on human chromosome 1p35.1. RBBP4 is also known as NURF55, RBAP48 and lin-53. The human RBBP4 gene encodes a 47656 Da protein containing 425 amino acids. The RBBP4 protein is ubiquitously expressed in testis, lymph node and other tissues. Among its related pathways are Regulation of TP53 Activity through Acetylation and E2F transcription factor network. RBBP4 is related to RNA polymerase II proximal promoter sequence-specific DNA binding and histone deacetylase binding. RBBP7 is an important paralog of RBBP4 gene. RBBP4 is associated with some diseases, including Retinoblastoma and Hemophagocytic Lymphohistiocytosis, Familial, 1.

RbAp48 Protein (2)

    RbAp48 Antibody (2)

      RbAp48 cDNA Clone (47)

      NM_005610.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_009030.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001107912.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001261038.1

      克隆载体 cDNA 产品

      In lentiviral vector

      RbAp48 Lysate (2)

        RbAp48 分子背景

        Histone-binding protein RBBP4, also known as Retinoblastoma-binding protein 4, Retinoblastoma-binding protein p48, Chromatin assembly factor 1 subunit C, Chromatin assembly factor I p48 subunit, Nucleosome-remodeling factor subunit RBAP48 and RBBP4, is a nucleus protein which belongs to the WD repeat RBAP46/RBAP48/MSI1 family. RBBP4 is a core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. RBBP4 is a component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling and the NURF (nucleosome remodeling factor) complex. One common myth is that age-related memory loss is an early indication of Alzheimer's disease. But researchers at the Columbia University Medical Center in New York City have found a specific protein, RbAp48, that they believe is responsible for age-related memory problems. What's more, by replenishing RbAp48 in the brains of mice, the researchers were able to undo existing age-related memory damage. To find RbAp48, researchers focused on the hippocampus, the region of the brain where memories are formed. After studying eight healthy brains donated to science by people between the ages of 33 and 88, they found that RbAp48 was reduced by nearly 5 percent in the older brains. The researchers found that when they turned off RbAp48 in younger mice, they became more forgetful, while increasing RbAp48 in older mice restored memory. The mice were given memory tests that included object recognition and water maze problems.

        RbAp48 参考文献

        • Rasmussen HH. et al.,1992, Electrophoresis 13:960-9.
        • Qian Y.-W. et al., 1993,  Nature 364:648-52.
        • Yarden R.I. et al., 1999, Proc. Natl. Acad. Sci. USA. 96: 4983-8.
        • Ota T. et al., 2004, Nat. Genet. 36:40-45.
        • Gauci S. et al., 2009, Anal. Chem. 81:4493-501.

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