RBP4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

RBP4 (Retinol Binding Protein 4) is a protein coding gene located on human chromosome 10q23.33. RBP4 is also known as RDCCAS and MCOPCB10. The human RBP4 gene encodes a 23010 Da protein containing 201 amino acids. The RBP4 protein is biasedly expressed in liver and fat. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. RBP4 is related to protein heterodimerization activity and retinol binding. RBP4 is associated with some diseases, including Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome and Microphthalmia, Isolated, With Coloboma 10.

RBP4 Protein (6)

RBP4 Antibody (20)

    RBP4 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

    RBP4 cDNA Clone (52)

    NM_006744.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_011255.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_013162.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_534969.2

    克隆载体 cDNA 产品

    In lentiviral vector

    RBP4 Lysate (6)

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      RBP4 分子背景

      Retinol-binding protein 4 (RBP4) is the specific carrier for retinol (also known as vitamin A), and is responsible for the conversion of unstable and insoluble retinol in aqueous solution into stable and soluble complex in plasma through their tight interaction. As a member of the lipocalin superfamily, RBP4 containing a β-barrel structure with a well-defined cavity is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), and this binding is crucial for preventing RBP4 excretion through the kidney glomeruli. RBP4 expressed from an ectopic source efficiently delivers retinol to the eyes, and its deficiency affects night vision largely. Recently, RBP4 as an adipokine, is found to be expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).

      RBP4 参考文献

      • Yang Q, et al. (2005) Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 436(7049): 356-62.
      • Choi SH, et al. (2008) High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab. 93(8): 3142-8.
      • Tepper BJ, et al. (2010) Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes. Clin Biochem. 43(3): 320-3.

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