REG1B Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

REG1B (Regenerating Family Member 1 Beta) is a protein coding gene located on human chromosome 2p12. REG1B is also known as REGH, REGL, PSPS2 and REGI-BETA. The human REG1B gene encodes a 18665 Da protein containing 166 amino acids. The REG1B protein is biasedly expressed in duodenum, small intestine and other tissues. REG1B is related to carbohydrate binding. REG1A is an important paralog of REG1B gene. REG1B is associated with some diseases, including Anaerobic Pneumonia and Pancreatitis.

REG1B Protein (3)

    REG1B Antibody (10)

      REG1B ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      REG1B cDNA Clone (26)

      NM_006507.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001194568.1

      克隆载体 cDNA 产品

      In lentiviral vector

      REG1B qPCR Primer (1)

      REG1B Lysate (3)

        REG1B 分子背景

        Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein that has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.

        REG1B 参考文献

        • Moriizumi S, et al. (1994) Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1217(2): 199-202.
        • Sanchez D, et al. (2001) Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun. 284(3): 729-37.
        • Boonyasrisawat W, et al. (2002) Analysis of the reg1alpha and reg1beta gene transcripts in patients with fibrocalculous pancreatopathy. Southeast Asian J Trop Med Public Health. 33(2): 365-72.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.