Ribonuclease A Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

RNASE1 (Ribonuclease A Family Member 1, Pancreatic) is a protein coding gene located on human chromosome 14q11.2. RNASE1 is also known as RAC1, RIB1 and RNS1. The human RNASE1 gene encodes a 17644 Da protein containing 156 amino acids. The RNASE1 protein is broadly expressed in pancreas, testis and other tissues. RNASE1 is related to nucleic acid binding and ribonuclease A activity. RNASE4 is an important paralog of RNASE1 gene. RNASE1 is associated with Osteopetrosis, Autosomal Dominant 1.

Ribonuclease A Protein (1)

    Ribonuclease A Antibody (3)

      Ribonuclease A ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      Ribonuclease A cDNA Clone (26)

      BC005324

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011271.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Ribonuclease A qPCR Primer (1)

      Ribonuclease A Lysate (1)

        Ribonuclease A 分子背景

        RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. RNase A is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

        Ribonuclease A 参考文献

        • Tubert P, et al. (2011) Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8. Biophys J. 101(2):459-67.
        • Vinayagam A, et al. (2011) A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 4(189):rs8.
        • Fischer S, et al. (2011) Expression and localisation of vascular ribonucleases in endothelial cells. Thromb Haemost. 105(2):345-55.

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