RSPO3 Proteins, cDNA Clones Research Reagents

RSPO3 (R-Spondin 3) is a protein coding gene located on human chromosome 6q22.33. RSPO3 is also known as PWTSR, THSD2 and CRISTIN1. The human RSPO3 gene encodes a 30929 Da protein containing 272 amino acids. The RSPO3 protein is broadly expressed in endometrium, placenta and other tissues. Among its related pathways are Signaling by GPCR and Signaling by Wnt. RSPO3 is related to signaling receptor binding and G protein-coupled receptor binding. RSPO2 is an important paralog of RSPO3 gene. RSPO3 is associated with Nail Disorder, Nonsyndromic Congenital, 4.

RSPO3 Protein (1)

    RSPO3 cDNA Clone (26)

    NM_032784.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_028351.2

    克隆载体 cDNA 产品

    In lentiviral vector

    RSPO3 Lysate (1)

      RSPO3 分子背景

      R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify signaling of Wnt3A, Wnt1, and Wnt7A, suggesting that RSPO proteins are general regulators of canonical Wnt signaling. RSPO3/PCP signaling during gastrulation requires Wnt5a and is transduced via Fz7, Dvl, and JNK. RSPO3 functions by inducing Sdc4-dependent, clathrin-mediated endocytosis. RSPO3 is a novel, evolutionarily conserved angiogenic factor in embryogenesis. RSPO3 has a key role in the interaction between chorion and allantois in labyrinthine development.

      RSPO3 参考文献

      • Aoki M, et al. (2007) R-spondin3 is required for mouse placental development. Dev Biol. 301(1): 218-26.
      • Kazanskaya O, et al. (2008) The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development. 135(22): 3655-64.
      • Kim KA, et al. (2008) R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell. 19(6): 2588-96.
      • Ohkawara B, et al. (2011) Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis. Dev Cell. 20(3): 303-14.

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