S100A12 Proteins, Antibodies, cDNA Clones Research Reagents

S100A12 (S100 Calcium Binding Protein A12) is a protein coding gene located on human chromosome 1q21.3. S100A12 is also known as p6, CAGC, CGRP, MRP6, CAAF1, MRP-6 and ENRAGE. The human S100A12 gene encodes a 10575 Da protein containing 92 amino acids. The S100A12 protein is restrictedly expressed toward bone marrow. Among its related pathways are Activated TLR4 signalling and Innate Immune System. S100A12 is related to calcium ion binding and RAGE receptor binding. S100A9 is an important paralog of S100A12 gene. S100A12 is associated with some diseases, including Kawasaki Disease and Mooren's Ulcer.

S100A12 Protein (1)

    S100A12 Antibody (4)

      S100A12 cDNA Clone (13)


      克隆载体 cDNA 产品

      In lentiviral vector

      S100A12 qPCR Primer (1)

      S100A12 分子背景

      S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of intracellular and extracellular functions. They are involved in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response. Protein S100-A12, also known as S100 calcium-binding protein A12, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, and S100A12, is a member of the S-101 family. Like the majority of S100 proteins, S100A12 is a dimer, with the interface between the two subunits being composed mostly of hydrophobic residues. The fold of S100A12 is similar to the other known crystal and solution structures of S100 proteins, except for the linker region between the two EF-hand motifs. S100A12 plays an important role in the inflammatory response.

      S100A12 参考文献

      • Moroz, OV. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57: 20-9.
      • Foell, D. et al., 2003, Lancet  361 (9365):1270-2.
      • Vogl, T. et al., 2004, Blood. 104: 4260-8.
      • Viemann, D. et al., 2005, Blood. 105: 2955-62.
      • Nakatani, Y. et al., 2005, Mediators Inflamm. 2005: 280-292.
      • Bjoerk, P. et al., 2009, PLoS Biol. 7: E97-E97.

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