S100A3 Proteins, Antibodies, cDNA Clones Research Reagents

All S100A3 reagents are produced in house and quality controlled, including 6 S100A3 Antibody, 30 S100A3 Gene, 2 S100A3 Protein, 2 S100A3 qPCR. All S100A3 reagents are ready to use.

S100A3 Protein (2)

    S100A3 Antibody (6)

      S100A3 cDNA Clone (30)

      NM_002960.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011310.2

      克隆载体 cDNA 产品

      In lentiviral vector

      S100A3 分子背景

      Protein S1-A3, also known as Protein S-1E, S1 calcium-binding protein A3, S1A3 and S1E, is a member of the S-1 family. S1A3 / S1E contains 2EF-hand domains. S1A3 / S1E is highly expressed in the differentiating cuticular cells within the hair follicle and organized into mature hair cuticles. High concentrations of S1A3 homotetramer might provide the millimolar level of Ca2+ required for hair cuticular barrier formation. S1A3 / S1E is a unique member of the Ca2+-binding S1 protein family with the highest cysteine content and affinity for Zn2+. S1A3 / S1E binds both calcium and zinc. S1A3 / S1E probably binds 2 zinc ions per molecule. It may be involved in calcium-dependent cuticle cell differentiation and hair shaft formation. S1A3 plays an important role in calcium-dependent processes leading to hair shaft formation. S1A3 / S1E is a unique protein among all members of the calcium-binding S1 family, is specifically expressed at the inner endocuticle of human hair fibers. Upon hair damage, S1A3 / S1E is released from hair fibers and possibly destabilizes the hair tissue architecture.

      S100A3 参考文献

      • Kizawa, K. et al., 2008, J Biol Chem. 283 (8):5004-13.
      • Kizawa, K. et al., 1998, J Invest Dermatol. 111 (5):879-86.
      • Kizawa, K. et al., 2002, Biochem Biophys Res Commun. 299 (5):857-62.
      • Fritz,G. et al., 2002, J Biol Chem. 277 (36):33092-8.

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