S100B-IHC抗体

产品编号 100508-R034
抗体名称 S100B蛋白抗体
免疫原 A synthetic peptide corresponding to the N-terminus of the human S100B
克隆号  
Ig类型 兔-IgG
克隆类型 多克隆抗体
应用 IHC-P稀释倍数: 1:200-1:1000
特异性 Human S100B

S100B-IHC抗体多组织验证图

阳性组织
小脑 神经鞘瘤1 胸腺 肾上腺1
 
皮肤 淋巴癌1 恶黑  
阴性组织
神经鞘瘤2 淋巴癌2 血管瘤 肾上腺2
       
平滑肌瘤        
阳性组织 脑、小脑、神经鞘瘤(供体1)、胸腺、肾上腺(供体1)、肾、皮肤、淋巴癌、恶性黑素瘤
阴性组织 肝、神经鞘瘤(供体2)、肾上腺(供体2)、平滑肌瘤、淋巴癌、血管瘤

S100B-IHC抗原介绍

抗原名称 S100B
背景介绍 S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
细胞定位 细胞核、细胞浆
结构特征 每 个 S100 蛋白由 2 个EF-手型钙结合部位组成,中间由 1 个连接器连接,第一个结合部位由螺旋Ⅰ( 钙离子结合部位) 和螺旋Ⅱ组成,具有较弱的钙离子结合能力,而第二个结合部位由螺旋Ⅲ-环-螺旋Ⅳ组成,具有较高的钙离子结合力。
功能 参与细胞增殖、分化、肌肉收缩、基因表达、分泌及细胞凋亡等过程,还有神经营养、信号调节因子的作用
研究领域 肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞周期蛋白

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