Secretogranin II Proteins, Antibodies, cDNA Clones Research Reagents

SCG2 (Secretogranin II) is a protein coding gene located on human chromosome 2q36.1. SCG2 is also known as SN, CHGC, EM66 and SgII. The human SCG2 gene encodes a 70941 Da protein containing 617 amino acids. The SCG2 protein is biasedly expressed in adrenal, brain and other tissues. SCG2 is related to cytokine activity and chemoattractant activity. SCG2 is associated with some diseases, including Collagenous Colitis and Intracranial Primitive Neuroectodermal Tumor.

Secretogranin II Protein (1)

    Secretogranin II Antibody (3)

      Secretogranin II cDNA Clone (13)


      克隆载体 cDNA 产品

      In lentiviral vector

      Secretogranin II qPCR Primer (1)

      Secretogranin II Lysate (1)

        Secretogranin II 分子背景

        Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell development depends on stem cell factor (Kit ligand) and its receptor, c-Kit. KITL / kit ligand stimulates the proliferation of mast cells. KITL / kit ligand is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Efficient cell surface presentation of KITL / kit ligand is essential for the migration, proliferation, and survival of melanocytes, germ cells, hemopoietic stem cells, and mastocytes. KITL / kit ligand acts synergistically with other cytokines, probably interleukins. KITL / kit ligand plays a crucial role in the development and maintenance of the melanocyte lineage in adult skin. It exerts permanent survival, proliferation and migration functions in Kit receptor-expressing melanocytes. KITL / kit ligand misexpression in some hyperpigmented lesions may open the avenue for Kitl-dependent treatment of pathological skin conditions.

        Secretogranin II 参考文献

        • Nishida, al., 2002, Blood. 99 (5):1866-9.
        • Paulhe,F. et al., 2004,J Biol Chem. 279 (53):55545-55.
        • Fernandez,S.M. et al., 2008,Biol Reprod. 79 (2):318-27.
        • Wehrle-Haller,B. et al., 2003,Pigment Cell Res.16 (3):287-96.

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