SELL/CD62L Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SELL (Selectin L) is a protein coding gene located on human chromosome 1q24.2. SELL is also known as TQ1, LAM1, LEU8, LNHR, LSEL, CD62L, LYAM1, PLNHR and LECAM1. The human SELL gene encodes a 42187 Da protein containing 372 amino acids. The SELL protein is biasedly expressed in lymph node, spleen and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Hematopoietic Stem Cells and Lineage-specific Markers. SELL is related to carbohydrate binding and protease binding. SELE is an important paralog of SELL gene. SELL is associated with some diseases, including Arthus Reaction and Cryptococcosis.

SELL/CD62L Protein (7)

    SELL/CD62L Antibody (24)

      SELL/CD62L ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

      SELL/CD62L cDNA Clone (41)

      BC020758

      In expression vector

      In lentiviral vector

      NM_011346.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_019177.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001042763.1

      克隆载体 cDNA 产品

      In lentiviral vector

      SELL/CD62L Lysate (7)

        SELL/CD62L 分子背景

        L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

        SELL/CD62L 参考文献

        • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
        • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.

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