Cortisol Binding Globulin Proteins, Antibodies, cDNA Clones Research Reagents

SERPINA6 (Serpin Family A Member 6) is a protein coding gene located on human chromosome 14q32.13. SERPINA6 is also known as CBG. The human SERPINA6 gene encodes a 45141 Da protein containing 405 amino acids. The SERPINA6 protein is biasedly expressed in liver, gall bladder and other tissue. Among its related pathways are Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics. SERPINA6 is related to serine-type endopeptidase inhibitor activity and steroid binding. SERPINA3 is an important paralog of SERPINA6 gene. SERPINA6 is associated with some diseases, including Corticosteroid-Binding Globulin Deficiency and Hyperthyroidism.

Cortisol Binding Globulin Protein (3)

    Cortisol Binding Globulin Antibody (7)

      Cortisol Binding Globulin cDNA Clone (26)

      NM_001756.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_007618.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Cortisol Binding Globulin Lysate (2)

        Cortisol Binding Globulin 分子背景

        Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.

        Cortisol Binding Globulin 参考文献

        • Seralini GE. (1991) A new role for corticosteroid binding globulin (CBG), member of SERPIN superfamily. C R Seances Soc Biol Fil. 185(6): 500-9.
        • Buss C, et al. (2007) Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency. J Neural Transm. 114(5): 563-9.
        • Torpy DJ, et al. (2007) Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders. Clin Endocrinol (Oxf). 67(2): 161-7.
        • Braun BC, et al. (2010) Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity. J Steroid Biochem Mol Biol. 120(1): 30-7.
        • Lin HY, et al. (2010) Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol. 316(1): 3-12.

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