Alpha 2 Antiplasmin/SerpinF2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SERPINF2 (Serpin Family F Member 2) is a protein coding gene located on human chromosome 17p13.3. SERPINF2 is also known as AAP, API, PLI, A2AP, and ALPHA-2-PI. The human SERPINF2 gene encodes a 54566 Da protein containing 491 amino acids. The SERPINF2 protein is biasedly expressed in liver and kidney. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Dissolution of Fibrin Clot. SERPINF2 is related to protein homodimerization activity and protease binding. SERPINF1 is an important paralog of SERPINF2 gene. SERPINF2 is associated with some diseases, including Alpha-2-Plasmin Inhibitor Deficiency and Livedoid Vasculitis.

All Alpha 2 Antiplasmin/SerpinF2 Reagents

Alpha 2 Antiplasmin/SerpinF2 Protein (3)

    Alpha 2 Antiplasmin/SerpinF2 Antibody (12)

      Alpha 2 Antiplasmin/SerpinF2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

      Alpha 2 Antiplasmin/SerpinF2 cDNA Clone (39)

      NM_000934.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008878.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001011892.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Alpha 2 Antiplasmin/SerpinF2 Lysate (3)

        Alpha 2 Antiplasmin/SerpinF2 分子背景

        SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta at a moderate level. It is indicated that Serpin F2 is a key regulator of plasmin-mediated proteolysis in these tissues. Alpha-2 AP is an unusual serpin in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. SerpinF2 is one of the inhibitors of fibrinolysis, which acts as the primary inhibitor of plasmin(ogen). It is a specific plasmin inhibitor, and is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin. Alpha-2 AP plays the dominant role in inhibiting both plasma clot lysis and thrombus lysis, and accordingly, the congenital deficiency of Alpha-2 antiplasmin causes a rare bleeding disorder because of increased fibrinolysis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases.

        Alpha 2 Antiplasmin/SerpinF2 参考文献

        • Lee KN, et al. (2004) Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal. Curr Med Chem Cardiovasc Hematol Agents. 2(4): 303-10.
        • Matsuno H. (2006) Alpha2-antiplasmin on cardiovascular diseases. Curr Pharm Des. 12(7): 841-7.
        • Burnouf T, et al. (2007) Impact of Triton X-100 on alpha 2-antiplasmin (SERPINF2) activity in solvent/detergent-treated plasma. Biologicals. 35(4): 349-53.
        • Carpenter SL, et al. (2008) Alpha2-antiplasmin and its deficiency: fibrinolysis out of balance. Haemophilia. 14(6): 1250-4.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.