SFRP4 Proteins, Antibodies, cDNA Clones Research Reagents

SFRP4 (Secreted Frizzled Related Protein 4) is a protein coding gene located on human chromosome 7p14.1. SFRP4 is also known as PYL, FRP-4, FRPHE, FRZB-2, and sFRP-4. The human SFRP4 gene encodes a 39827 Da protein containing 346 amino acids. The SFRP4 protein is biasedly expressed in endometrium, ovary and other tissue. Among its related pathways are Wnt signaling pathway and Adipogenesis. SFRP4 is related to G protein-coupled receptor activity and Wnt-protein binding. FRZB is an important paralog of SFRP4 gene. SFRP4 is associated with some diseases, including Pyle Disease and Osteomalacia.

SFRP4 Protein (3)

    SFRP4 Antibody (2)

      SFRP4 cDNA Clone (26)


      克隆载体 cDNA 产品

      In lentiviral vector


      克隆载体 cDNA 产品

      In lentiviral vector

      SFRP4 Lysate (3)

        SFRP4 分子背景

        SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. SFRP4 is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins called FZ domain and a NTR domain. Mouse SFRP4 is highly expressed in the ovary, and is localized to granulosa cells of periovulatory follicles and corpora lutea. It plays a critical role in placental development and implantation, and is also an important factor in the development of the decidual fibrinoid zone, and in trophoblast apoptosis.

        SFRP4 参考文献

        • Abu-Jawdeh G.M., et al.,(1999), Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Lab. Invest. 79:439-447.
        • Berndt T., et al., (2003), Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.J. Clin. Invest. 112:785-794.
        • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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