SGK1/SGK Antibodies, cDNA Clones Research Reagents

SGK1 (Serum/Glucocorticoid Regulated Kinase 1, also known as SGK), located on 6q23.2, is a Protein Coding gene. This gene encodes a serine/threonine-protein kinase that plays an important role in cellular stress response. SGK1, that encodes a putative 431-amino acid protein with a molecular mass of 49 kD. The protein sequence of SGK1was found to be 98% identical to that of the rat sgk protein, a novel member of the serine/threonine-protein kinase family regulated by serum and glucocorticoids in a rat mammary tumor cell line.

SGK1/SGK Antibody (1)

    SGK1/SGK cDNA Clone (43)

    NM_005627.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_011361.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_019232.3

    克隆载体 cDNA 产品

    In lentiviral vector

    SGK1/SGK 分子背景

    Serum- and glucocorticoid-inducible kinase 1 (SGK1), a protein kinase, shares significant structural similarity with other members of the AGC protein kinase family. The inactive SGK1 structure lacks the αC helix and this unique feature makes it distinct from other protein kinases. SGK1 is ubiquitously expressed, which plays a pivotal role in the hormonal regulation of several ion channels, carriers, pumps, and transcription factors or regulators. SGK1 plays an important role in the absorption of Na+ and water through the Na+ channel in the apical membrane of tubular epithelial cells. SGK1 expression is modulated by cell stress and hormones, including gluco- and mineralocorticoids. Compelling evidence suggests that increased SGK1 expression or function is related to the pathogenic stress hypothesis of major depression.

    SGK1/SGK 参考文献

    • Tang Z, et al. (2018) Serum and glucocorticoid-regulated kinase 1 (sgk1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with sgk1 inhibitor and γ-ray irradiation was elucidated. Oncol Rep 39 (3): 1505-1515.
    • Martín-Fernández B, et al. (2014) Relevance of sgk1 in structural, functional and molecular alterations produced by aldosterone in heart. Horm Mol Biol Clin Investig 18 (2): 53-61.
    • Dattilo V, et al. (2020) The emerging role of sgk1 (serum- and glucocorticoid-regulated kinase 1) in major depressive disorder: Hypothesis and mechanisms. Front Genet 11 826.
    • Akhoon BA, et al. (2019) Computational insights into the active structure of sgk1 and its implication for ligand design. Biochimie 165 57-66.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.