SIGLEC5 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5) is a protein coding gene located on human chromosome 19q13.41. SIGLEC5 is also known as CD170, OBBP2, CD33L2, OB-BP2, and SIGLEC-5. The human SIGLEC5 gene encodes a 60715 Da protein containing 551 amino acids. The SIGLEC5 protein is biasedly expressed in bone marrow, spleen and other tissues. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. SIGLEC5 is related to carbohydrate binding. ENSG00000268500 is an important paralog of SIGLEC5 gene. SIGLEC5 is associated with some diseases, including Ovarian Cystic Teratoma and Herpetic Whitlow.

SIGLEC5 Protein (2)

    SIGLEC5 Antibody (11)

      SIGLEC5 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      SIGLEC5 cDNA Clone (14)

      NM_003830.3

      克隆载体 cDNA 产品

      NM_145581.1

      克隆载体 cDNA 产品

      In lentiviral vector

      SIGLEC5 qPCR Primer (1)

      SIGLEC5 Lysate (2)

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        SIGLEC5 分子背景

        SIGLEC5 contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. It belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC5 is expressed by monocytic/myeloid lineage cells. It is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is also expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

        SIGLEC5 参考文献

        • Angata T, et al. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20(12):1964-73.
        • Avril T, et al. (2005) Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. J Biol Chem. 280(20):19843-51.
        • Erickson-Miller CL, et al. (2003) Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Exp Hematol. 31(5):382-8.

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