SIGNR1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All SIGNR1 reagents are produced in house and quality controlled, including 6 SIGNR1 Antibody, 1 SIGNR1 ELISA, 13 SIGNR1 Gene, 1 SIGNR1 Lysate, 1 SIGNR1 Protein, 1 SIGNR1 qPCR. All SIGNR1 reagents are ready to use.

SIGNR1 Protein (1)

    SIGNR1 Antibody (6)

      SIGNR1 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      SIGNR1 cDNA Clone (13)

      NM_026972.3

      克隆载体 cDNA 产品

      In lentiviral vector

      SIGNR1 qPCR Primer (1)

      SIGNR1 Lysate (1)

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        SIGNR1 分子背景

        The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD209b, also known as SIGNR1, is a C-type lectin receptor. CD209b is present on most regions of mouse brain and found on microglia and dendritic cells but not on neurons or astrocytes. CD209b is implicated in the recently described SIGNR1 complement activation pathway, which operates against capsular polysaccharides in splenic marginal macrophages. CD209b in rat is homologue to SIGNR1 in mouse, both of which are found to mediate the uptake of dextran or CPS14 within the splenic marginal zone.

        SIGNR1 参考文献

        • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
        • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
        • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
        • Park JY, et al. (2009) The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumonia. Neuroscience Letters. 450 (3): 246-51.

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