SIRP gamma/SIRPG Proteins, Antibodies, cDNA Clones Research Reagents

SIRPG (Signal Regulatory Protein Gamma) is a protein coding gene located on human chromosome 20p13. SIRPG is also known as CD172g, SIRPB2, SIRP-B2, bA77C3.1, and SIRPgamma. The human SIRPG gene encodes a 42498 Da protein containing 387 amino acids. The SIRPG protein is biasedly expressed in lymph node, appendix and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. SIRPB1 is an important paralog of SIRPG gene.

SIRP gamma/SIRPG Protein (5)

    SIRP gamma/SIRPG Antibody (3)

      SIRP gamma/SIRPG cDNA Clone (28)

      NM_018556.3

      克隆载体 cDNA 产品

      In lentiviral vector

      BC064532

      In expression vector

      In lentiviral vector

      XM_001113667.2

      克隆载体 cDNA 产品

      In lentiviral vector

      SIRP gamma/SIRPG qPCR Primer (1)

      SIRP gamma/SIRPG Lysate (5)

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        SIRP gamma/SIRPG 分子背景

        Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. SIRPG/SIRP gamma/CD172g is a probable immunoglobulin-like cell surface receptor. On binding with CD47, SIRPG can mediate cell-cell adhesion. SIRPG/SIRP gamma is engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. SIRPG/SIRP gamma/CD172g is detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. This cytokine is mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, SIRPG is primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

        SIRP gamma/SIRPG 参考文献

        • Meador JA, et al. (2011) p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiat Res. 175(6): 689-99.
        • Reddy MV, et al. (2011) Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes Immun. 12(3): 208-12.
        • Kawasaki M, et al. (2009) Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus. Clin Exp Rheumatol. 27(2): 260-6.

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