SLC5A1 Antibodies, cDNA Clones Research Reagents

SLC5A1 (Solute Carrier Family 5 Member 1, also known as NAGT; SGLT1; D22S675), located on 22q12.3, is a Protein Coding gene. The gene produces a 73498 Da protein composed of 664 amino acids. The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells. The SLC5A1 protein contains a core of 13 transmembrane domains, which it shares with other members of the gene family, and it contains an additional transmembrane appended to the C terminus.

SLC5A1 Antibody (1)

    SLC5A1 cDNA Clone (13)

    NM_000343.3

    克隆载体 cDNA 产品

    In lentiviral vector

    SLC5A1 qPCR Primer (1)

    SLC5A1 分子背景

    Sodium-glucose cotransporters SGLT1 (encoded by SGLT1, also known as SLC5A1) and SGLT2 (encoded by SGLT2, also known as SLC5A2) are important mediators of epithelial glucose transport. Mutations in the SLC5A1 gene cause glucose/galactose malabsorption, whereas mutations in SLC5A2 are associated with glucosuria. Congenital glucose-galactose malabsorption (cGGM) is a rare autosomal recessive disorder, caused by mutations in the Na(+)/glucose cotransporter gene SLC5A1, which may result in severe life-threatening osmotic diarrhea due to the accumulation of unabsorbed sugars in the intestinal lumen. If treated early with the elimination of glucose and galactose from the diet, patients usually recover and develop normally. More than 300 subjects of diverse origin have been reported worldwide, most of whom are a result of a consanguineous union.

    SLC5A1 参考文献

    • Xin B, et al. (2011) Multiple sequence variations in slc5a1 gene are associated with glucose-galactose malabsorption in a large cohort of old order amish. Clin Genet 79 (1): 86-91.
    • Vallaeys L, et al. (2013) Congenital glucose-galactose malabsorption: A novel deletion within the slc5a1 gene. Eur J Pediatr 172 (3): 409-411.
    • Pode-Shakked B, et al. (2014) Bitterness of glucose/galactose: Novel mutations in the slc5a1 gene. J Pediatr Gastroenterol Nutr 58 (1): 57-60.
    • Al-Suyufi Y, et al. (2018) Slc5a1 mutations in saudi arabian patients with congenital glucose-galactose malabsorption. J Pediatr Gastroenterol Nutr 66 (2): 250-252.

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