SLPI Proteins, Antibodies, cDNA Clones Research Reagents

SLPI (Secretory Leukocyte Peptidase Inhibitor) is a protein coding gene located on human chromosome 20q13.12. SLPI is also known as ALP, MPI, ALK1, BLPI, HUSI, WAP4, WFDC4 and HUSI-I. The human SLPI gene encodes a 14326 Da protein containing 132 amino acids. The SLPI protein is biasedly expressed in salivary gland, lung and other tissues. Among its related pathways are Innate Immune System. SLPI is related to enzyme binding and endopeptidase inhibitor activity. WFDC3 is an important paralog of SLPI gene. SLPI is associated with some diseases, including Renal Osteodystrophy and Pustular Psoriasis.

SLPI Protein (2)

    SLPI Antibody (3)

      SLPI cDNA Clone (13)

      NM_003064.2

      克隆载体 cDNA 产品

      In lentiviral vector

      SLPI qPCR Primer (1)

      SLPI Lysate (2)

        SLPI 分子背景

        Secretory leukoprotease inhibitor (SLPI), also called antileukoprotease (ALP), is a 12-kDa, nonglycosylated serine protease inhibitor present in mucous secretions. It is thought to play a role in protecting the mucosae from injury associated with inflammation. SLPI is locally produced by serous cells, including bronchial submucosal glands. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. Elafin and SLPI are structurally related in that both have a fold with a four-disulfide core or whey acidic protein (WAP) domain responsible for inhibiting proteases. SLPI is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity.

        SLPI 参考文献

        • Moreau T, et al. (2008) Multifaceted roles of human elafin and secretory leukocyte proteinase inhibitor (SLPI), two serine protease inhibitors of the chelonianin family. Biochimie. 90(2): 284-95.
        • Weldon S, et al. (2007) Innate host defense functions of secretory leucoprotease inhibitor. Exp Lung Res. 33(10): 485-91.
        • Williams SE, et al. (2006) SLPI and elafin: one glove, many fingers. Clin Sci (Lond). 110(1): 21-35.
        • Kikuchi T, et al. (1996) Regulation of secretory leukoprotease inhibitor gene expression. Nihon Rinsho. 54(2): 405-10.

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