SMAD7 - epigenetic modified gene related to atherosclerosis. SMAD7 methylation as a novel marker in atherosclerosis and further elucidate the role of Hcy in atherogenesis. Atherosclerosis is a complicated process comprising inflammation, accumulation of collagen matrix and aberrant DNA methylation. SMAD7 is known to play an important role in fibrosis and inflammation. SMAD7 may be a novel predicted marker and therapeutic target for atherosclerosis. SMAD7 attenuated the TGF-beta signaling pathway in ovarian granulosa cells (GCs) by regulating TGFBR1 transcriptional activity.