SOD2/Mn-SOD Proteins, Antibodies, cDNA Clones Research Reagents

SOD2 (Superoxide Dismutase 2) is a protein coding gene located on human chromosome 6q25.3. SOD2 is also known as IPOB, IPO-B, MNSOD, MVCD6, GClnc1 and Mn-SOD. The human SOD2 gene encodes a 24750 Da protein containing 222 amino acids. The SOD2 protein is ubiquitously expressed in appendix, bone marrow and other tissues. Among its related pathways are Folate Metabolism and Neurodegenerative Diseases. SOD2 is related to identical protein binding and oxygen binding. ENSG00000285441 is an important paralog of SOD2 gene. SOD2 is associated with some diseases, including Microvascular Complications Of Diabetes 6 and Gastric Cancer.

SOD2/Mn-SOD Protein (1)

    SOD2/Mn-SOD Antibody (4)

      SOD2/Mn-SOD cDNA Clone (46)

      NM_000636

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001322816.1

      克隆载体 cDNA 产品

      NM_013671.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_017051.2

      克隆载体 cDNA 产品

      In lentiviral vector

      SOD2/Mn-SOD 分子背景

      Superoxide dismutases (SOD) are important anti-oxidant enzymes that guard against superoxide toxicity. In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. Mitochondrial superoxide dismutase [SOD; manganese SOD (MnSOD) or SOD2] neutralizes highly reactive superoxide radical (O•-2), the first member in the plethora of mitochondrial reactive oxygen species.

      SOD2/Mn-SOD 参考文献

      • Culotta VC, et al. (2006) Activation of superoxide dismutases: putting the metal to the pedal. Biochim Biophys Acta. 1763(7): 747-58.
      • Bag A, et al. (2008) Target sequence polymorphism of human manganese superoxide dismutase gene and its association with cancer risk: a review. Cancer Epidemiol Biomarkers Prev. 17(12): 3298-305.
      • Diehl C, et al. (2009) The basis of topical superoxide dismutase antipruritic activity. Acta Dermatovenerol Croat. 17(1): 25-39.
      • Ma X, et al. (2010) No association between SOD2 Val16Ala polymorphism and breast cancer susceptibility: a meta-analysis based on 9,710 cases and 11,041 controls. Breast Cancer Res Treat. 122(2): 509-14.

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