SPINK4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SPINK4 (Serine Peptidase Inhibitor Kazal Type 4) is a protein coding gene located on human chromosome 9p13.3. SPINK4 is also known as PEC60, HEL136 and PEC-60. The human SPINK4 gene encodes a 9454 Da protein containing 86 amino acids. The SPINK4 protein is biasedly expressed in colon, small intestine and other tissues. SPINK4 is related to serine-type endopeptidase inhibitor activity.

SPINK4 Protein (3)

    SPINK4 Antibody (5)

      SPINK4 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      SPINK4 cDNA Clone (26)

      NM_014471.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_011463.2

      克隆载体 cDNA 产品

      In lentiviral vector

      SPINK4 Lysate (3)

        SPINK4 分子背景

        Serine protease inhibitor Kazal-type 4, also known as Peptide PEC-6 homolog and SPINK4, is a secreted protein that contains one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged infertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.

        SPINK4 参考文献

        • Schneider, A. et al., 2004,Gastroenterol Clin North Am. 33 (4): 789-806.
        • Wapenaar, MC. et al., 2007, Immunogenetics. 59 (5): 349-57.
        • Brattsand, M. et al., 2009, J Invest Dermatol. 129 (7): 1656-65.
        • Chen, T. et al., 2009, Proteins. 77 (1): 209-19.
        • Noah, TK. et al., 2010, Exp Cell Res. 316 (3): 452-65.

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