Src Proteins, Antibodies, cDNA Clones Research Reagents

SRC (SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase) is a protein coding gene located on human chromosome 20q11.23. SRC is also known as ASV, SRC1, THC6, c-SRC, and p60-Src. The human SRC gene encodes a 59835 Da protein containing 536 amino acids. The SRC protein is ubiquitously expressed in stomach, testis and other tissues. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Negative regulation of MAPK pathway. SRC is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. YES1 is an important paralog of SRC gene. SRC is associated with some diseases, including Thrombocytopenia 6 and Myelofibrosis.

Src Protein (2)

    Src Antibody (2)

      Src cDNA Clone (44)


      克隆载体 cDNA 产品

      In lentiviral vector


      In expression vector


      克隆载体 cDNA 产品

      In lentiviral vector


      克隆载体 cDNA 产品

      In lentiviral vector

      Src Lysate (2)

        Src 分子背景

        Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.

        Src 参考文献

        • Juan Ma. et al., 2003, Neuroscience Letters. 348 (3): 185-189.
        • Czernilofsky AP. et al., 1980, Nature. 287: 198-203.
        • Beischlag TV. et al., 2002, Molecular and cellular biology. 22 (12): 4319-33.

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